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The co-Key efficacy endpoints have been the p.c reduction in inflammatory lesion counts and proportion of topics with achievements on IGA, defined as an IGA score of 0 (“obvious”) or one ( “Nearly crystal clear”) at Week ten. The efficacy results are demonstrated in the following table:
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disulfiram will increase toxicity of metronidazole topical by reducing metabolism. Slight/Significance Unknown. Increased CNS & cardiac toxicity with oral metronidazole and disulfiram; not as likely to manifest with topical administration because of low absorption.
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